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. 2020 Apr 2;11:537. doi: 10.3389/fimmu.2020.00537

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Copyright © 2020 Liu, Xu, Liang, Liu, Zhao, Ma and Gao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Functions and related signaling pathways of Tim-4 in various cells and diseases. Microenvironments of tumor and NAFLD enhanced Tim-4 expression in APC, TAM, TADC, tumor cells greatly, and expression of Tim-4 in APC, bound to surface PS of apoptotic cell, exosome, virus to induce signaling communication. NAFLD, Non-alcoholic fatty liver disease; APC, Antigen-presenting cell; TAM/DC, Tumor associated macrophage/dendritic cell; PS, Phosphatidylserine; SEB, Staphylococcal enterotoxin B; CT, Cholera toxin; PE, Peanut extract.