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. 2020 Apr 2;14:74. doi: 10.3389/fncel.2020.00074

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Copyright © 2020 Tognatta, Karl, Fyffe-Maricich, Popratiloff, Garrison, Schenck, Abu-Rub and Miller.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Astrocyte loss in vivo resulted in local disruption of myelin integrity. (A) Experimental design. (B,C) Compared to control segments (B,B’), CID treated segments of GFAP-iCP9 animals had a reduction in GFAP+ cells (C) and reduction in MBP expression (C’). (D,E) Representative toluidine blue stained images of 1μm spinal cord sections from adult GFAP-iCP9 mice after intrathecal injection of CID. Local astrocyte loss resulted in loss of myelin (D) and myelin decompaction (E). (F,G) Ultrastructural analysis confirms loss of myelin integrity while axons remain morphologically relatively normal (G). Scale Bars: (D) 20 μm; (E) 5 μm; (F) 5 μm; (G) 1 μm; (B,C) 200 μm.