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. 2020 Mar 26;2020:8131286. doi: 10.1155/2020/8131286

Figure 4.

Figure 4

Ambroxol reduces white matter fiber bundle damage in mice with ICH. (a) The representative immunostaining showed MBP expression around the hematoma after ICH in different groups. Scale bar: 50 μm. (b) Quantification of MBP+ area per high power field according to the immunostaining, ∗∗p < 0.01, n = 4. (c) Transmission electron micrographs (TEM) of myelin sheath in ipsilateral basal ganglia from each group mouse brain tissue. The red arrows mark the phenomenon of demyelination. TEM shows the myelin sheath around the hematoma are thinned and disintegrated post-ICH in mice. Scale bars: ((c) 1, 2, and 3) 500 nm; ((c) 4) 1 μm. a: axon. (d) Statistical graph for G-ratio to evaluate the myelin sheath. ∗∗p < 0.01, n = 4.