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. 2020 Apr 2;14:280. doi: 10.3389/fnins.2020.00280

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Copyright © 2020 Kestner, Mayser, Vutukuri, Hansen, Günther, Brunkhorst, Devraj and Pfeilschifter.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Top-regulated genes and pathways in the acute and postacute stage post-stroke after DESEQ2 normalization. (A) Z-score of top 25 up- and top 25 downregulated genes in the ipsilateral hemisphere of tMCAO- versus sham-operated animals 24 h post-surgery and gene set enrichment within the identified genes. (B) Z-score of top 25 up- and top 25 downregulated genes in the ipsilateral hemisphere of tMCAO- versus sham-operated animals 7 days post-surgery and gene set enrichment within the identified genes. Transcripts accepted as regulated: mean > 5 counts, log₂fc <> ±0.585, FDR ≤ 0.05. Exemplary genes and gene sets are highlighted (arrows).