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. 2020 Apr 7;2020:3908641. doi: 10.1155/2020/3908641

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Copyright © 2020 Nan Song et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Study protocol. Part I: neonatal rat cardiomyocytes were subjected to OGD/R, and rats underwent myocardial I/R. Part II: the p38 MAPK inhibitor (SB203580) was used 1 h prior to OGD in cells or before myocardial ischemia in rats. Part III: cells were transfected with Hsp70 shRNA for 48 h and treated with SB203580 1 h prior to OGD, and rats received Quercetin (an Hsp70 inhibitor) and SB203580 1 h prior to myocardial ischemia. OGD/R: oxygen-glucose deprivation/reoxygenation; I/R: ischemia/reperfusion.