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. 2020 Apr 7;2020:3908641. doi: 10.1155/2020/3908641

Figure 10.

Figure 10

Exacerbation of I/R-induced myocardial injury by Hsp70 inhibition was abolished by p38 MAPK inhibition. (a) Representative Evans blue/TTC staining images. (b) Quercetin, an Hsp70 inhibitor, further increased myocardial infarct size, which was blocked by SB203580. (c) SB203580 blocked quercetin-induced increase in serum cTnI. (d) SB203580 inhibited quercetin-induced increase in [Ca2+]i level. (e and f) SB203580 suppressed quercetin-induced IL-1β and IL-6 mRNA activation. (g) Representative TUNEL staining images. Scale bar = 50 μm. (h) SB203580 reversed quercetin-induced elevation in cell apoptosis. n = 5. Data are shown as means ± SEM. ∗P < 0.05, ∗∗P < 0.01 vs. the sham group; ##P < 0.01 vs. the I/R group; &P < 0.05, &&P < 0.01 vs. the Que + I/R group. I/R: ischemia/reperfusion; AAR: area at risk; LV: left ventricle; IA: infarct area.