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. 2020 Apr 7;2020:3908641. doi: 10.1155/2020/3908641

Figure 4.

Figure 4

p38 MAPK inhibition alleviated OGD/R-induced injury, [Ca2+]i overload, and apoptosis in cardiomyocytes. (a) SB203580, a p38 MAPK inhibitor, increased cell viability during OGD/R (n = 8). (b) SB203580 reduced OGD/R-induced LDH release (n = 8). (c) SB203580 inhibited OGD/R-induced [Ca2+]i elevation (n = 5). (d and e) SB203580 reduced IL-1β and IL-6 mRNA expression during OGD/R (n = 5). (f) Representative TUNEL staining images. Scale bar = 50 μm. (g) SB203580 inhibited OGD/R-induced cell apoptosis (n = 5). Data are shown as means ± SEM. ∗P < 0.05, ∗∗P < 0.01 vs. the control group; #P < 0.05, ##P < 0.01 vs. the OGD/R group. OGD/R: oxygen-glucose deprivation/reoxygenation.