Table A1.
SNP genotypic association with early onset asthma using different cutoff for age diagnosed.
| SNP | Genotype | Risk of Early Onset Asthma among Subjects with Childhood ETS Exposure (n = 230) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Age (in years) Diagnosed | |||||||||||
| ≤ 8 | ≤ 9 | ≤ 10 | ≤ 11 | ≤ 12 | |||||||
| OR * | p-Value * | OR * | p-Value * | OR * | p-Value * | OR * | p-Value * | OR * | p-Value * | ||
| rs2234678 | AG&AA | 1 | 1 | 1 | 1 | 1 | |||||
| GG | 4.941 | 0.014 | 4.941 | 0.014 | 4.467 | 0.021 | 4.395 | 0.023 | 4.149 | 0.031 | |
| rs392503 | AA&AG | 1 | 1 | 1 | 1 | 1 | |||||
| GG | 5.157 | 0.007 | 5.157 | 0.007 | 4.577 | 0.012 | 4.474 | 0.013 | 4.196 | 0.019 | |
| rs1794067 | GG&AG | 1 | 1 | 1 | 1 | 1 | |||||
| AA | 3.506 | 0.02 | 3.506 | 0.02 | 3.123 | 0.032 | 2.978 | 0.041 | 2.819 | 0.05 | |
* Logistic regression adjusted for age, BMI, gender, education, AIMs (5PCs). OR: odds ratio. Bold number for p-value means statistically significant at the 5% level.