Table A1.
OR (95% CI) for hearing loss by RTL levels stratified by sex and age.
| RTL Levels | Case/Control | For Male | Case/Control | For Female | |||
|---|---|---|---|---|---|---|---|
| OR (95% CI) | p-Trend | OR (95% CI) | p-Trend | ||||
| For age ≤ 60y | |||||||
| Per doubling | 299/297 | 0.80 (0.55–1.16) | 0.234 | 283/283 | 0.58 (0.39–0.88) | 0.009 | |
| Per SD | 299/297 | 0.86 (0.71–1.05) | 0.133 | 283/283 | 0.75 (0.60–0.94) | 0.013 | |
| For age > 60y | |||||||
| Per doubling | 112/114 | 0.70 (0.39–1.27) | 0.243 | 123/123 | 0.45 (0.24–0.86) | 0.016 | |
| Per SD | 112/114 | 0.87 (0.58–1.32) | 0.514 | 123/123 | 0.60 (0.41–0.89) | 0.011 | |
| Total | |||||||
| Per doubling | 411/411 | 0.78 (0.57–1.07) | 0.120 | 406/406 | 0.54 (0.38–0.76) | <0.001 | |
| Per SD | 411/411 | 0.87 (0.73–1.04) | 0.122 | 406/406 | 0.71 (0.58–0.86) | 0.001 | |
| Quartile | |||||||
| Q1 (≤0.711) | 111/95 | 1 (reference) | Q1 (≤0.736) | 114/90 | 1 (reference) | ||
| Q2 (0.711–0.922) | 104/107 | 0.76 (0.50–1.17) | Q2 (0.736–0.968) | 109/94 | 0.77 (0.51–1.17) | ||
| Q3 (0.922–1.172) | 99/101 | 0.77 (0.50–1.19) | Q3 (0.968–1.212) | 96/102 | 0.65 (0.42–1.01) | ||
| Q4 (>1.172) | 97/108 | 0.68 (0.42–1.09) | 0.426 | Q4 (>1.212) | 87/120 | 0.45 (0.28–0.73) | 0.011 |
Abbreviations: RTL, relative telomere length; OR, odds ratio; CI, confidence interval; Adjusted for hypertension, hyperlipidemia, diabetes, hypercholesterolemia and cadmium. We modeled RTL as a continuous variable (per one standard deviation [SD] increase). One SD of RTL = 0.347.