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. 2020 Mar 31;12:57. doi: 10.3389/fnagi.2020.00057

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Copyright © 2020 Yang, Stanford and Jiang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Low-normal total cholesterol (TC) levels correlated with reduced gray matter volume (GMv) in three medial temporal regions in the low TC (lTC) group. Three significant clusters were identified, including the bilateral anterior hippocampus (HIP)/parahippocampal cortex (HPC), and the right inferior temporal lobe (ITL). Age, gender, education years, Geriatric Depression Scale, patient category, whether or not taking medicine for lowering cholesterol, apolipoprotein (APO)E ε4 carrier status, and brain size were controlled (see section “Materials and Methods”). Thresholds, p < 0.001 (Threshold-Free Cluster Enhancement, uncorrected, voxel-wise), p < 0.05 [family-wise error rate (FWE) corrected at cluster level], and cluster size (≥50 voxels). TFCE, threshold-free cluster enhancement.