Table 1.
Demographic and physiologic characteristics (n=5,716)
| Baseline Characteristics |
ε2/2 or ε2/3 (n=775) |
ε2/4 (n=135) |
ε3/3 (n=3508) |
ε3/4 or ε4/4 (n=1298) |
Total (n=5716) |
p-value |
|---|---|---|---|---|---|---|
| Age at baseline (SD) | 70.70 (4.04) | 70.61 (4.19) | 70.55 (3.83) | 70.33 (3.68) | 70.52 (3.84) | 0.153 |
| Education (%) | 0.95 | |||||
| < High school | 40 (5.17) | 10 (7.41) | 208 (5.94) | 68 (5.26) | 326 (5.72) | |
| High school/GED | 182 (23.5) | 29 (21.5) | 761 (21.7) | 290 (22.4) | 1262 (22.1) | |
| Some college | 312 (40.4) | 55 (40.7) | 1413 (40.4) | 531 (41.1) | 2311 (40.5) | |
| College grad | 239 (30.9) | 41 (30.4) | 1117 (31.9) | 404 (31.2) | 1801 (31.6) | |
| Prior HT use (%) | 0.365 | |||||
| Never used hormones | 437 (56.4) | 79 (58.5) | 1873 (53.4) | 719 (55.4) | 3108 (54.4) | |
| Past hormone user | 297 (38.3) | 45 (33.3) | 1400 (39.9) | 501 (38.6) | 2243 (39.3) | |
| Current hormone user | 41 (5.29) | 11 (8.15) | 233 (6.65) | 78 (6.01) | 363 (6.35) | |
| Trial Variables | ||||||
| Prior Hysterectomy (%) | 271 (35.0) | 53 (39.3) | 1311 (37.4) | 488 (37.6) | 2123 (37.1) | 0.568 |
| HT Randomization assignment (%) | 384 (49.5) | 67 (49.6) | 1725 (49.2) | 645 (49.7) | 2821 (49.4) | 0.989 |
| Lifestyle Factors | ||||||
| Sleep Disturbance Construct (SD) | 7.31 (4.31) | 7.04 (4.61) | 6.95 (4.56) | 6.85 (4.34) | 6.98 (4.48) | 0.154 |
| Cardiovascular Risk Factors | ||||||
| Body-mass Index (BMI), kg/m2 (SD) | 28.44 (5.65) | 28.46 (6.11) | 28.43 (5.47) | 28.25 (6.05) | 28.39 (5.64) | 0.810 |
| Systolic BP (SD) | 131.5 (18.16) | 131.7 (17.82) | 131.8 (17.54) | 132.9 (17.26) | 132.0 (17.57) | 0.202 |
| Diastolic BP (SD) | 74.87 (9.19) | 74.83 (8.93) | 74.56 (9.16) | 74.91 (9.39) | 74.69 (9.21) | 0.637 |
| Stroke (%) | 10 (1.29) | 2 (1.48) | 54 (1.54) | 17 (1.31) | 83 (1.45) | 0.916 |
| Hypertension (%) | 365 (47.1) | 63 (46.7) | 1643 (46.8) | 649 (50.0) | 2720 (47.6) | 0.268 |
| Diabetes (%) | 62 (8.00) | 10 (7.41) | 269 (7.67) | 72 (5.55) | 413 (7.23) | 0.066 |
| High cholesterol (%) | 74 (9.70) | 12 (9.02) | 657 (19.0) | 288 (22.4) | 1031 (18.3) | <.001 |
| LDL Cholesterol (SD) | 132.4 (32.50) | 142.5 (40.55) | 152.6 (34.83) | 157.8 (35.73) | 150.8 (35.72) | <.001 |
| HDL Cholesterol (SD) | 55.67 (13.28) | 52.90 (12.78) | 53.97 (12.65) | 52.72 (12.84) | 53.89 (12.81) | <.001 |
| Physical function | ||||||
| Physical Functioning Construct (SD) | 78.63 (19.93) | 76.31 (19.48) | 78.40 (20.18) | 77.89 (20.55) | 78.26 (20.21) | 0.551 |
| MET-hours per week from walking (SD) | 4.32 (5.66) | 3.83 (5.57) | 4.20 (5.63) | 4.24 (5.45) | 4.22 (5.59) | 0.806 |
| Episodes moderate to strenuous phys activity per week (SD) | 2.52 (3.24) | 1.95 (2.80) | 2.47 (3.13) | 2.37 (3.05) | 2.44 (3.12) | 0.194 |
| Episodes moderate to strenuous activity ≥ 20 min/week (SD) | 1.91 (2.92) | 1.53 (2.68) | 1.91 (2.91) | 1.84 (2.79) | 1.89 (2.88) | 0.435 |
| Energy/Fatigue (SD) | 64.54 (18.28) | 61.15 (20.09) | 64.06 (18.74) | 65.10 (17.34) | 64.29 (18.41) | 0.072 |
| Well-being | ||||||
| Emotional Well-being (SD) | 81.04 (13.08) | 81.08 (12.97) | 81.19 (13.23) | 81.25 (12.64) | 81.18 (13.07) | 0.988 |
| Satisfied with quality of life (SD) | 8.16 (1.86) | 8.30 (1.69) | 8.23 (1.79) | 8.24 (1.75) | 8.22 (1.79) | 0.688 |
| Rate quality of life (SD) | 8.26 (1.43) | 8.41 (1.36) | 8.31 (1.42) | 8.31 (1.34) | 8.31 (1.40) | 0.670 |
| General Health Construct (SD) | 75.67 (16.21) | 73.14 (17.96) | 75.40 (15.90) | 75.67 (15.66) | 75.45 (15.94) | 0.362 |
| Pain Construct (SD) | 75.00 (22.13) | 73.61 (23.44) | 75.46 (21.91) | 74.76 (22.44) | 75.19 (22.10) | 0.627 |
| Shortened CES-D/DIS Screening Instrument (SD) | 0.03 (0.09) | 0.04 (0.10) | 0.03 (0.10) | 0.03 (0.10) | 0.03 (0.10) | 0.591 |
| Stressors | ||||||
| Currently helping a sick, limited, or frail family member on a regular basis (%) | 285 (37.2) | 51 (37.8) | 1437 (41.3) | 553 (42.8) | 2326 (41.0) | 0.066 |
| Number of times per week currently helps a friend or family member (SD) | 0.87 (1.32) | 1.01 (1.44) | 0.99 (1.37) | 1.04 (1.40) | 0.99 (1.37) | 0.063 |
| Life Event Construct #2 (0-3 scoring) (SD) | 3.02 (2.90) | 3.36 (3.17) | 2.84 (2.82) | 2.98 (2.95) | 2.91 (2.87) | 0.072 |
| Life Event Construct #1 (0,1 scoring) (SD) | 1.56 (1.33) | 1.76 (1.46) | 1.47 (1.30) | 1.53 (1.35) | 1.51 (1.32) | 0.031 |
| Cognitive function | ||||||
| Baseline 3MS score (SD) | 96.06 (3.51) | 95.63 (4.16) | 95.81 (3.67) | 95.68 (3.98) | 95.81 (3.73) | 0.139 |
| Most severe adjudicated cognitive status (%) | <.001 | |||||
| Normal | 667 (86.1) | 114 (84.4) | 2989 (85.2) | 984 (75.8) | 4754 (83.2) | |
| MCI | 53 (6.84) | 8 (5.93) | 220 (6.27) | 109 (8.40) | 390 (6.82) | |
| Probable Dementia | 55 (7.10) | 13 (9.63) | 299 (8.52) | 205 (15.8) | 572 (10.0) |
Abbreviations: 3MS= Modified Mini Mental State Exam; BP=blood pressure; CES-D=Center for Epidemiologic Studies Depression Scale; DIS=Diagnostic Interview Schedule; GED=general equivalency diploma; HDL=high density lipoprotein; HT=hormone therapy; LDL=low density lipoprotein; MCI=mild cognitive impairment; MET=metabolic equivalent of task; SD=Standard Deviation.