Table 2.
Logistic Regression Models modeling Survivorship among ε3/4 and ε4/4 participants (n=451 versus 106)
| Model 1 | Model 2 | Model 3a | Model 3b | |||||
|---|---|---|---|---|---|---|---|---|
| Variable | OR (95% CI) | p-value | OR (95% CI) | p-value | OR (95% CI) | p-value | OR (95% CI) | p-value |
| APOE | 0.025 | 0.105 | ||||||
| ε3/4 | 2.41 (1.12, 5.19) | 2.14 (0.85, 5.35) | ||||||
| ε4/4 | 1.0 | 1.0 | ||||||
| Time to Impairment or Age 80 | 1.21 (1.13, 1.29) | <.001 | 1.10 (1.02, 1.19) | 0.016 | 1.12 (1.05, 1.20) | 0.001 | 1.12 (1.05, 1.19) | 0.001 |
| Education | 0.259 | 0.686 | 0.592 | 0.767 | ||||
| < High school | 1.06 (0.33, 3.42) | 1.71 (0.42, 7.00) | 1.66 (0.52, 5.26) | 1.49 (0.50, 4.49) | ||||
| High school/GED | 0.61 (0.32, 1.15) | 0.82 (0.38, 1.78) | 0.84 (0.44, 1.62) | 0.90 (0.48, 1.66) | ||||
| Some college | 1.11 (0.62, 1.98) | 1.13 (0.58, 2.23) | 1.17 (0.65, 2.09) | 1.12 (0.64, 1.96) | ||||
| College grad | 1.00 | 1.00 | 1.00 | 1.00 | ||||
| Randomization assignment | 0.38 | 0.474 | 0.522 | 0.611 | ||||
| HT | 0.81 (0.50, 1.30) | 0.82 (0.47, 1.42) | 0.85 (0.53, 1.38) | 0.89 (0.56, 1.40) | ||||
| Placebo | 1.00 | 1.00 | 1.00 | 1.00 | ||||
| Region | 0.122 | 0.131 | ||||||
| Northeast | 0.55 (0.27, 1.11) | 0.58 (0.26, 1.27) | ||||||
| South | 0.63 (0.32, 1.26) | 0.77 (0.35, 1.67) | ||||||
| Midwest | 0.42 (0.20, 0.86) | 0.38 (0.16, 0.88) | ||||||
| West | 1.00 | 1.00 | ||||||
| Hysterectomy status | 0.463 | 0.755 | ||||||
| No | 0.83 (0.50, 1.38) | 0.91 (0.51, 1.63) | ||||||
| Yes | 1.00 | 1.00 | ||||||
| Prior HT use | 0.284 | 0.358 | ||||||
| Curr. HT user | 0.57 (0.17, 1.84) | 0.75 (0.19, 2.90) | ||||||
| Never used HT | 0.68 (0.40, 1.14) | 0.64 (0.35, 1.18) | ||||||
| Past HT user | 1.00 | 1.00 | ||||||
| Cardiovascular Risk Factors for Dementia | ||||||||
| Body-mass Index (BMI), kg/m2 | 1.00 (0.96, 1.05) | 0.914 | 0.99 (0.94, 1.03) | 0.546 | ||||
| Systolic BP | 1.01 (0.99, 1.03) | 0.421 | 1.01 (0.99, 1.04) | 0.254 | ||||
| Diastolic BP | 0.99 (0.96, 1.02) | 0.633 | 0.99 (0.95, 1.02) | 0.437 | ||||
| History of hypertension | 0.410 | 0.544 | ||||||
| No | 1.30 (0.70, 2.41) | 1.25 (0.61, 2.56) | ||||||
| Yes | 1.00 | 1.00 | ||||||
| History of diabetes | 0.031 | 0.073 | ||||||
| No | 2.65 (1.09, 6.42) | 2.53 (0.92, 6.96) | ||||||
| Yes | 1.00 | 1.00 | ||||||
| History of high cholesterol | 0.931 | 0.354 | ||||||
| No | 0.97 (0.54, 1.75) | 0.72 (0.36, 1.45) | ||||||
| Yes | 1.00 | 1.00 | ||||||
| LDL Cholesterol | 1.00 (1.00, 1.01) | 0.446 | 1.00 (0.99, 1.01) | 0.928 | ||||
| HDL Cholesterol | 1.00 (0.98, 1.02) | 0.956 | 1.00 (0.98, 1.02) | 0.982 | ||||
| History of stroke | 0.094 | 0.382 | ||||||
| No | 3.71 (0.80, 17.19) | 2.29 (0.36, 14.57) | ||||||
| Yes | 1.00 | 1.00 | ||||||
| Lifestyle Factors | 0.994 | |||||||
| Alcohol use | 0.86 (0.25, 2.88) | |||||||
| Non | 0.97 (0.33, 2.86) | |||||||
| Past | 0.93 (0.37, 2.32) | |||||||
| Up to <7 drinks | 0.86 (0.25, 2.88) | |||||||
| 7+ drinks | 1.00 | |||||||
| Cigarette smoking | 0.463 | |||||||
| Current Smoker | 0.58 (0.17, 2.05) | |||||||
| Never Smoked | 0.71 (0.39, 1.30) | |||||||
| Past Smoker | 1.00 | |||||||
| Physical Function | ||||||||
| MET-hours per week from walking | 0.96 (0.92, 1.01) | 0.087 | ||||||
| Well-being | ||||||||
| Emotional Well-being | 1.02 (0.99, 1.05) | 0.150 | ||||||
| Rate quality of life | 0.97 (0.74, 1.26) | 0.798 | ||||||
| General Health Construct | 1.02 (1.00, 1.04) | 0.057 | 1.02 (1.01, 1.04) | 0.004 | 1.03 (1.01, 1.04) | 0.001 | ||
| Shortened CES-D/DIS Screening Instrument | 1.74 (0.95, 3.19) | 0.072 | ||||||
| Cognitive Function | ||||||||
| Baseline 3MS score | 1.20 (1.13, 1.27) | <.001 | 1.18 (1.12, 1.25) | <.001 | 1.16 (1.11, 1.22) | <.001 | ||
Model 1: APOE and Time to Impairment or Age 80, treatment arm, education, region, hysterectomy, prior HT, BMI, hx of stroke, systolic BP, diastolic BP, hx of hypertension, hx of diabetes, hx of high cholesterol, HDL, LDL
Model 2: Includes Model 1 plus physical function including MET-hours per week from walking and lifestyle factors including emotional well-being, rated quality of life, smoking, drinking (4 groups: non, past, up to <7 drinks (group all), and 7+ drinks), general health, CESD (0.1 unit increase), 3MS
Model 3a: Reduced model, retaining only significant and key factors (including Time to Impairment or Age 80, edu, trt status)
Model 3b: Includes women who developed impairment after age 80, n=623 versus 106.
Abbreviations: 3MS= Modified Mini Mental State Exam; BP=blood pressure; CES-D=Center for Epidemiologic Studies Depression Scale; DIS=Diagnostic Interview Schedule; edu=education; GED=general equivalency diploma; HDL=high density lipoprotein; HT=hormone therapy; hx=history; LDL=low density lipoprotein; MCI=mild cognitive impairment; MET=metabolic equivalent of task; trt=treatment.