Figure 6.

Therapeutic targeting of the hallmarks of cancer drugs that interfere with each of the acquired capabilities necessary for tumor growth and progression have been developed and are in clinical trials or in some cases approved for clinical use in treating certain forms of human cancer. Additionally, the investigational drugs are being developed to target each of the enabling characteristics and emerging hallmarks depicted in Figure 3, which also hold promise as cancer therapeutics. The drugs listed are but illustrative examples; there is a deep pipeline of candidate drugs with different molecular targets and modes of action in development for most of these hallmarks. Reproduced with permission from Hanahan & Weinberg. Hallmarks of Cancer: The Next Generation, Cell 144, 4 March 2011 Elsevier Inc. 2011,144(5), 646–674 (215).