Figure 4.

Histopathological findings regarding colon of mice treated for 7 days with Saline solution [(A) Control group post-TNBS (4×), magnification 4×; (B) Control group post-TNBS (10×), magnification 10×, histological score 6] or bovine colostrum [(C) Bovine Colostrum group post-TNBS (4×), magnification 4×; (D) Bovine Colostrum group post-TNBS (10×), magnification 10×, histological score 4] and then inoculated with TNBS show significant high but not always a constant amount of diffuse inflammation. The structure of the mucosa often appears modified by a massive diffuse inflammatory infiltrate of lymphocytes which involves also the submucosa and the intestinal wall. In the BC group, the diffuse inflammatory infiltrate of lymphocitary cells reaches the submucosa. Panels (A,B): enteritis with a high grade of diffuse inflammation and massive lymphocyte infiltration of all structures of the colon. The architectural structure of the mucosa is modified by the infiltration of the inflammatory cells. The submucosa, the intestinal wall and the serosal parts appear to be involved by the lymphocytary cells. Panels (C,D): enteritis with a medium grade of inflammatory infiltration involving the mucosa and the sub-mucosa of the colon.