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The time course of the dose-dependent analgesic effect of conotoxin-Ac1 and conotoxin-Ac1-O6P in mice. (a) The dose-dependent analgesic effect of conotoxin-Ac1 by hot-plate method. (b) The dose-dependent analgesia effect of conotoxin-Ac1-O6P by hot-plate method. (c) The dose-dependent analgesic effect of conotoxin-Ac1 by tail-flick method. (d) The dose-dependent analgesia effect of conotoxin-Ac1-O6P by tail-flick method.
