Figure 1.

Sixty-five years of antifungal therapy. Most antifungal agents were discovered in the most recent three decades. Colored dots refer to specific antifungal drug class—polyenes (blue), pyrimidine analogues (purple), triazoles (green), and echinocandins (orange). Antifungal drugs under development and/or testing in clinical trials are marked black (see the chapter Antifungal pipeline for further information). AMB = amphotericin B, 5-FC = flucytosine, FLC = fluconazole, ITC = itraconazole, CSF = caspofungin, VOR = voriconazole, MCF = micafungin, POS = posaconazole, ANF = anidulafungin, ISV = isavuconazole, SUBA-ITC = super bioavailable itraconazole.