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The MPP10-MRX12 locus on Chromosome X. (A) The spatial arrangement of the ribosome biogenesis gene pair, MPP10-MRX12, highlighting the promoter regulatory elements. (B) Comparison of the potential effects that can arise from a loss of the proper transcriptional regulation of this gene pair. The loss of stoichiometric levels of these genes necessary for ribosome production is wasteful and could potentially alter cellular proteostasis.
