Observations by confocal microscopy to evaluate the interaction between J774 macrophase and CDs-coated MOFs, indicating that hybrid materials have penetrated into macrophase and affected its functions. Cells were stained in green with calcein, the cell nucleus is in black, and the rhodamine-B-labeled hybrid materials exhibited red signals. The differences of images (a–c) of the same cells caused by three different heights above the glass slide including 2.3, 4.9 and 7.6 µm, respectively. Scale bar = 5 µm. Reproduced from Reference [18] with permission from the Nature Publishing Group, copyright 2015.