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. 2020 Mar 15;8(3):415. doi: 10.3390/microorganisms8030415

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Elimination kinetics of individual patients. Lines show fitted first decay elimination curves. (A): normalized elimination kinetics. Patient ID, t_1/2, estimated glomerular filtration rate (GFR) (eGFR) at the beginning of elimination kinetics and mode of renal replacement therapy (RRT) is indicated. (B) Effect of initiation of renal replacement therapy (RRT) on Colistin elimination. After 60 h (dashed line) RRT was started within the elimination period. The blue line is the interpolated elimination kinetic without RRT. Backwards interpolation of samples obtained under RRT (red line) led to an assumed elimination kinetic of Colistin under RRT. CVVHDF = continuous venovenous hemodiafiltration.