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Perturbation of DNA fidelity and cellular regulation by pyrimidine deamination events.
| Canonical State | Protective Factors | Post-Error State | Consequence of Error | Repair Measure |
|---|---|---|---|---|
| C:G base-pair | dsDNA state or protein complex | U:G mistmatch | promutagenic | UDG |
| 5-me C:G base-pair | dsDNA state or protein complex | T:G mismatch | promutagenic | TDG |
| T:A base-pair | dUTPase and DNA polymerase | U:A base-pair | dysregulatory | UDG |
