Table 1.
Effect of chokeberry juice or silymarin on hepatic lipid peroxidation and antioxidant enzymes in the liver of rats treated with carbon tetrachloride.
| Treatment | LPO | Enzymes | ||||
|---|---|---|---|---|---|---|
| SOD | CAT | GPx | GR | GST | ||
| Controls | 0.21 ± 0.03 | 32.9 ± 4.8 | 4.13 ± 0.33 | 821.0 ± 83.0 | 54.4 ± 6.3 | 903.3 ± 63.9 |
| CCl4 | 0.31 ± 0.06 a | 7.2 ± 1.2 a | 2.12 ±0.34 a | 427.7 ± 48.9 a | 46.0 ± 5.3 | 585.8 ± 62.4 a |
| (T) | (↑48%) | (↓78%) | (↓49%) | (↓48%) | (↓16%) | (↓35%) |
| Chokeberry | 0. 21 ± 0.02 | 29.1 ± 3.1 | 4.83 ± 0.43 a | 882.2 ± 65.3 a | 44.8 ± 7.0 | 755.6 ± 29.4 a |
| juice | — | (↓12%) | (↑17%) | — | (↓18%) | (↓16%) |
| (A) | ||||||
| – | ||||||
| CCl4 + | 0.14 ± 0.03 b | 12.3 ± 2.4 b | 1.79 ± 0.27 | 440.5 ± 41.4 | 54.9 ± 3.7 b | 576.7 ± 52.2 |
| chokeberry | (↓55%) | (↑71%) | (↓16%) | (↑19%) | (↑19%) | — |
| juice | ||||||
| (A + T) | ||||||
| Silymarin | 0.14 ± 0,02 a | 35.0 ± 6.1 | 4.73 ± 0.25a | 978.2 ± 84.1 a | 51.1 ± 7.4 | 820.2 ± 57.3 |
| (S) | (↓33%) | — | (↑15%) | (↑19%) | — | — |
| CCl4 + | 0.16 ± 0.03 b | 19.7 ± 4.7 b | 2.27 ± 0.21 | 535.6 ± 46.0 b | 54.7 ± 3.1 b | 472.4 ± 60.3 b |
| silymarin | (↓48%) | (↑174%) | — | (↑25%) | (↑19%) | (↓19%) |
| (S+T) | ||||||
Results are means ± SD, n = 8. Control rats were administered water. a The juice-, silymarin-, and CCl4-treated groups are compared with controls, p < 0.05. b The CCl4-treated group is compared with the juice + CCl4- and silymarin + CCl4-treated groups, p < 0.05. Values in parentheses express the percentage of statistically significant change. The level of lipid peroxidation is expressed as nmol TBARS/min/mg protein. The activity of antioxidant enzymes is expressed as follows: SOD, CAT—U/mg protein; GPx, GR—nmol NADPH/min/mg protein; GST—nmol CDNB/min/mg protein.