Table 2.
Effect of chokeberry juice or silymarin on serum parameters in rats treated with carbon tetrachloride.
| Treatment | ||||||
|---|---|---|---|---|---|---|
| Parameters | Controls | CCl4 | Chokeberry | CCl4 + | Silymarin | CCl4 + |
| Juice | Chokeberry | Silymarin | ||||
| (T) | (A) | Juice | (S) | (S + T) | ||
| (A + T) | ||||||
| ALT | 60.1 ± 10.2 | 886 ± 95.7 a | 56.3 ± 9.4 | 838 ± 104 | 49.4 ± 4.5 | 881 ± 89.0 |
| (IU/L) | (↑1374%) | |||||
| AST | 78.7 ± 12.3 | 3401 ± 319a | 86.6 ± 4.0 | 1722 ± 194 b | 76.2 ± 15.7 | 1378 ± 216 b |
| (IU/L) | (↑3766%) | (↓49%) | (↓55%) | |||
| ALP | 190.9 ± 22.7 | 844 ± 84.1 a | 209.0 ± 35.7 | 772 ± 54.6 | 222 ± 16.2 | 820 ± 72.2 |
| (IU/L) | (↑342%) | |||||
| LDH | 183.0 ± 20.0 | 804 ± 96.3 a | 161.7 ± 24.4 | 364 ± 31.5 b | 154 ± 28.0 | 624 ± 55.9 b |
| (IU/L) | (↑339%) | (↓55%) | (↓22%) | |||
| GGT | 10.1 ± 1.0 | 36.9 ± 6.5 a | 8.2 ± 1.2 | 30.2 ± 2.0 b | 8.7 ± 1.0 | 20.3 ± 2.4 b |
| (IU/L) | (↑364%) | (↓18%) | (↓45%) | |||
| SDH | 7.9 ± 1.2 | 415 ± 67.5 a | 6.9 ± 1.4 | 234 ± 36.2 b | 3.9 ± 0.7 | 358 ± 38.3 |
| (IU/L) | (↑5136%) | (↓44%) | ||||
| Bilirubin | 0.32 ± 0.1 | 2.17 ± 0,2 a | 0.38 ± 0.1 | 1.48 ± 0.19 b | 0.29 ± 0.1 | 1.51 ± 0.2 b |
| (mg/dL) | (↑584%) | (↓32%) | (↓30%) | |||
| Cholesterol | 92.7 ± 4.3 | 123 ± 7.3 a | 83.6 ± 5.0 a | 112 ± 4.3 b | 83.8 ± 4.5 a | 109 ± 7.3 b |
| (mg/dL) | (↑33%) | (↓10%) | (↓9%) | (↓10%) | (↓11%) |
Results are means ± SD, n = 8. Control rats were administered water. a The juice-, silymarin-, and CCl4-treated groups are compared with controls, p < 0.05. b The CCl4-treated group is compared with the juice + CCl4- and silymarin + CCl4-treated groups, p < 0.05. Values in parentheses indicate the percentage of statistically significant change.