Scheme 5.
i: NH2OH∙HCl, pyridine (94%); ii: DIBAL-H, anhydrous CH2Cl2 (97% for two steps); iii: 2-bromo-benzaldehyde, Pd(OAc)2 (7.5 mol%), S-Phos (16, 10 mol%), Cs2CO3, TBAB, anhydrous 1,4-dioxane, reflux (87%).
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