Table 3.
Hazard ratios of incident CKD events by quartiles of FEV1 in men (n = 20,700)
| Q4 (reference) |
Q3 | Q2 | Q1 | P value for trend | ||
|---|---|---|---|---|---|---|
| 4.51(±0.42) | 3.79(±0.14) | 3.31(±0.14) | 2.58(±0.44) | |||
| Number (n) | 20,700 | 4813 | 5176 | 5388 | 5323 | – |
|
Incident CKD: Main diagnosis (n = 710) |
CKD events n (n per 1000 person-years) | 130 (0.82) | 167 (1.00) | 191 (1.16) | 222 (1.52) | |
| Unadjusted | 1.00 | 1.26 (1.00–1.58) | 1.56 (1.25–1.95) | 2.40 (1.93–2.98) | < 0.001 | |
| Adjusteda | 1.00 | 1.09 (0.86–1.38) | 1.19 (0.94–1.52) | 1.46 (1.14–1.89) | 0.002 | |
|
Incident CKD: Main or secondary diagnosis (n = 1021) |
CKD events n (n per 1000 person-years) | 183 (1.15) | 241 (1.45) | 287 (1.74) | 310 (2.13) | |
| Unadjusted | 1.00 | 1.29 (1.06–1.56) | 1.68 (1.40–2.02) | 2.41 (2.01–2.89) | 0.000 | |
| Adjusteda | 1.00 | 1.10 (0.90–1.33) | 1.24 (1.02–1.52) | 1.43 (1.16–1.77) | < 0.001 |
aAdjustments: Age, baseline eGFR, height, BMI, smoking status, cholesterol, history of CVD, history of diabetes, systolic BP, physical activity, social class, ESR (log transformed), BP medication, screening year
Incident CKD events: includes both inpatient hospitalisations and outpatient diagnosis. Main diagnosis = Primary diagnosis, Main or secondary diagnosis = Primary diagnosis or 1st-3rd secondary diagnosis