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Synthesis of 2-methyl-4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)phenyl ester of 3-(3-substituted isoxazol-5-yl)propionic acids 12a,b. Reagents and conditions: (a) NH2OH·HCl, K2CO3, EtOHabs, reflux; (b) (CF3CO)2O, pyridine, 80–90 °C; (c) 4-pentynoic acid, DCC, pyridine, rt; (d) 2-chloro-2-(hydroxyimino)acetic acid ethyl ester 5, Et3N, DMF, 80–90 °C; (e) acetaldoxime, N-chlorosuccinimide, pyridinecat, Et3N, DMF, 80–90 °C.
