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Superimposition of the β5i subunit of human IP (blue, PDB code 5M2B) and Mtb proteasome β subunit (grey, PDB code 6ODE) showing high similarity between the two enzymes and their active sites. The respective ligands Ro19 (purple) and B6 (green) are also presented. Catalytic threonine residues (Thr1) are red.
