Table 1. Twenty Most Highly Predicted Protein Targets Predicted from PCM Modeling for Cassia-Derived Anthraquinones in Neurodegenerative Diseasesa.
| organismal system | abbreviation | protein name | NR |
|---|---|---|---|
| STS | V1AR | vasopressin V1A receptor | 2.1742 |
| STS | SPR | substance P receptor | 1.9936 |
| NS | 5-HT-1A | 5-hydroxytryptamine receptor 1A | 1.9824 |
| STS | NKR | neuromedin-K receptor | 1.9311 |
| STS | OT-R | oxytocin receptor | 1.9099 |
| STS | MAPK14 | mitogen-activated protein kinase 14 | 1.8689 |
| STS, NS | 5-HT-6 | 5-hydroxytryptamine receptor 6 | 1.8408 |
| NS | DRD3 | D3 dopamine receptor | 1.8323 |
| STS, NS | 5-HT-2B | 5-hydroxytryptamine receptor 2B | 1.7906 |
| STS, NS | 5-HT-4 | 5-hydroxytryptamine receptor 4 | 1.7508 |
| NS | 5-HT-1B | 5-hydroxytryptamine receptor 1B | 1.7354 |
| STS | PI3K-α | phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic α-subunit | 1.7316 |
| STS, NS | ACM5 | muscarinic acetylcholine receptor M5 | 1.7278 |
| STS | NTR1 | neurotensin receptor type 1 | 1.7278 |
| STS, NS | DRD1 | D1 dopamine receptor | 1.7278 |
| STS | CysLTR1 | cysteinyl leukotriene receptor 1 | 1.7128 |
| STS, NS | 5-HT-2A | 5-hydroxytryptamine receptor 2A | 1.7128 |
| NS | 5-HT-3A | 5-hydroxytryptamine receptor 3A | 1.7128 |
| STS | HSP90 | heat shock protein HSP 90-α | 1.7054 |
| NS | ACM4 | muscarinic acetylcholine receptor M4 | 1.6980 |
a
NR: Normalization rate; NS: Nervous system; STS: Signaling transduction system.