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. 2020 Mar 24;5(13):7307–7315. doi: 10.1021/acsomega.9b04153

Table 3. Pharmacokinetic Parameters of a Single Dose of Psoralen in Rats (n = 6)^a.

		psoralen
parameter	unit	14 mg/kg	28 mg/kg	56 mg/kg
AUC(0-t)	mg/L^ah	57.35 ± 40.48	148.33 ± 51.99	203.55 ± 97.42
AUC(0-∞)	mg/L^ah	58.31 ± 40.65	156.62 ± 53.51	216.27 ± 111.91
MRT(0-t)	h	4.54 ± 0.88	6.90 ± 1.20 *	7.51 ± 1.05 **
MRT(0-∞)	h	4.76 ± 0.77	7.82 ± 1.66 *	8.58 ± 1.93 *
t_1/2	h	2.29 ± 0.81	3.70 ± 1.62	4.51 ± 1.88
T_max	h	2.83 ± 1.29	4.17 ± 1.83	3.33 ± 1.03
V_Z/F	L/kg	1.09 ± 0.69	1.10 ± 0.66	1.79 ± 0.48
CL_Z/F	L/h/kg	0.33 ± 0.17	0.20 ± 0.08	0.32 ± 0.15
C_max	mg/L	7.96 ± 4.39	14.82 ± 5.97	19.77 ± 7.98

^a

*p < 0.05, **p < 0.01 vs 14 mg/kg group.