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. 2020 Mar 24;5(13):7307–7315. doi: 10.1021/acsomega.9b04153

Table 4. Pharmacokinetic Parameters of Multiple Doses of Psoralen in Rats (n = 6)^a.

		psoralen
parameter	unit	14 mg/kg	28 mg/kg	56 mg/kg
AUC(0-t)	mg/L^ah	22.75 ± 1.40	201.61 ± 115.68	233.40 ± 51.75 **
AUC(0-∞)	mg/L^ah	42.53 ± 27.50	406.77 ± 32.47	502.90 ± 269.59
MRT(0-t)	h	5.67 ± 2.05	9.94 ± 2.15 ***	11.06 ± 1.36 ***
MRT(0-∞)	h	12.09 ± 6.41	26.93 ± 16.96	33.84 ± 24.87
t_1/2	h	6.44 ± 3.37	17.52 ± 12.91	21.15 ± 15.79
T_max	h	6.25 ± 4.50	5.92 ± 3.47	12.00 ± 6.57 ***
V_Z/F	L/kg	3.91 ± 2.04	2.00 ± 1.17	3.20 ± 0.80
CL_Z/F	L/h/kg	0.54 ± 0.51	0.12 ± 0.11	0.14 ± 0.059
C_max	mg/L	3.15 ± 1.15	13.30 ± 6.35	12.98 ± 3.38 **

^a

*p < 0.05, **p < 0.01 vs 14 mg/kg group, ***p < 0.001 vs 28 mg/kg group.