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Differential inhibition of AKR1B1 by synthetic and natural compounds. The bars refer to the differential inhibition between aldoses reduction and HNE reduction. The letters along the bars refer to: a: D-glyceramide15; b: D-gluconamide15; c: pyrazol[1,5-a]pyrimidine derivative (compound 5e52); d: soyasaponin55; e: NHDC20; f: sorbinil52; g: epalrestat52; h: [1,2,4]oxadiazol-5-yl-acetic acid derivative (compound 915); i: Saccharin derivative (compound 1615).
