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. Author manuscript; available in PMC: 2020 Apr 9.
Published in final edited form as: J Neural Eng. 2019 Apr 10;16(4):046003. doi: 10.1088/1741-2552/ab1834

Figure 6.

Figure 6.

Multi-patch electrophysiology. (a) Representative two-manipulator PatcherBot experiment in cultured HEK cells. Left dashed line encircles cells patch-clamped by pipette 1 (P1); right dashed line encircles cells patch-clamped by pipette 2 (P2). Cells are shown in an XY coordinate system because they are effectively in the same z plane on the coverslip. Green cell symbols represent successful whole-cell recordings; red symbols represent failed attempts. Pipettes not to scale. (b) Experimental and simulated results of multi-patch system scalability. From simulations, the largest increases in whole-cell recordings/hour are predicted in going from 1 to 2 manipulators (5.7 cells h−1), 2 to 3 (4.1 cells h−1) and 3 to 4 (3.1 cells h−1).