Table 2.
The top 10 significantly up- and down-regulated mRNAs in sea cucumber under the three treatment groups.
| Gene ID | Gene name | Pfam name | Pfam description | Fold change | P-value | ||
|---|---|---|---|---|---|---|---|
| HT | Up | AJAP20068 | Unknown | Corona_S2 | Coronavirus S2 glycoprotein | 399.0754 | 0.000154 |
| AJAP29379 | RNA-directed DNA polymerase from mobile element jockey-like | DUF3516 | Domain of unknown function (DUF3516) | 168.8633 | 0.000298 | ||
| AJAP27125 | Uncharacterized protein LOC593642 isoform X2 | CAP | Cysteine-rich secretory protein family | 146.4026 | 4.83E-05 | ||
| AJAP07685 | Unknown | DUF1720 | Domain of unknown function (DUF1720) | 125.6113 | 0.000141 | ||
| AJAP27361 | Heparan sulfate 2-O-sulfotransferase 1-like | DUF221 | Domain of unknown function DUF221 | 123.6578 | 0.000229 | ||
| AJAP09488 | Putative uncharacterized transposon-derived protein F52C9.6 | RVT_1 | Reverse transcriptase (RNA-dependent DNA polymerase) | 114.1713 | 0.000249 | ||
| AJAP22103 | Complement factor B | HlyIII | Haemolysin-III related | 97.26164 | 2.02E-17 | ||
| AJAP01587 | Galactosylceramide sulfotransferase isoform X1 | Gal-3-0_sulfotr | Galactose-3-O-sulfotransferase | 89.54334 | 0.00011 | ||
| AJAP20812 | Uncharacterized protein LOC105447293 | 7tm_7 | 7tm Chemosensory receptor | 78.97268 | 1.61E-07 | ||
| AJAP13651 | Heat shock protein 70 | HSP70 | Hsp70 protein | 69.91213 | 6.07E-17 | ||
| Down | AJAP18992 | Fatty acid-binding protein 2 | Lipocalin_7 | Lipocalin/cytosolic fatty-acid binding protein family | 0.000601 | 1.93E-22 | |
| AJAP00664 | Fibrillin-1 | NIDO | Nidogen-like | 0.002927 | 0.000208 | ||
| AJAP04725 | Orthodenticle | TF_Otx | Otx1 transcription factor | 0.003162 | 9.33E-09 | ||
| AJAP05915 | RING finger protein 207 | zf-B_box | B-box zinc finger | 0.003856 | 1.01E-06 | ||
| AJAP23548 | Unknown | L6_membrane | L6 membrane protein | 0.004067 | 2.12E-07 | ||
| AJAP25354 | Egg coat matrix protein | F5_F8_type_C | F5/8 type C domain | 0.004268 | 2.03E-06 | ||
| AJAP03163 | G2/mitotic-specific cyclin-B-like | Cyclin_N | Cyclin, N-terminal domain | 0.004395 | 2.60E-05 | ||
| AJAP24609 | Serine/threonine-protein kinase Nek4 isoform X5 | Pkinase | Protein kinase domain | 0.004731 | 2.01E-06 | ||
| AJAP28660 | Unknown | Cytadhesin_P30 | Cytadhesin P30/P32 | 0.004934 | 1.51E-06 | ||
| AJAP18483 | Hypothetical protein NEMVEDRAFT_v1g77984 | DUF946 | Plant protein of unknown function (DUF946) | 0.00715 | 3.48E-06 | ||
| LO | Up | AJAP02284 | Unknown | Ldl_recept_a | Low-density lipoprotein receptor domain class A | 352.4156 | 1.45E-08 |
| AJAP27125 | Uncharacterized protein LOC593642 isoform X2 | CAP | Cysteine-rich secretory protein family | 297.2703 | 5.08E-08 | ||
| AJAP16209 | Fibrinogen C domain-containing protein 1-like isoform X3 | Fibrinogen_C | Fibrinogen beta and gamma chains, C-terminal globular domain | 173.9777 | 1.14E-05 | ||
| AJAP20068 | Unknown | Corona_S2 | Coronavirus S2 glycoprotein | 132.2862 | 0.00052 | ||
| AJAP05639 | Unknown | Methyltransf_15 | RNA cap guanine-N2 methyltransferase | 131.738 | 1.22E-06 | ||
| AJAP23198 | Uncharacterized protein LOC105439756 | THAP | THAP domain | 106.7272 | 1.65E-08 | ||
| AJAP29377 | Unknown | Med6 | MED6 mediator sub complex component | 104.7819 | 0.000239 | ||
| AJAP24721 | Glutamate receptor 1 | Lig_chan | Ligand-gated ion channel | 97.99706 | 6.50E-09 | ||
| AJAP22103 | Complement factor B | HlyIII | Haemolysin-III related | 87.21897 | 5.02E-19 | ||
| AJAP01650 | 5-Hydroxytryptamine receptor 1-like | 7tm_1 | 7 transmembrane receptor (rhodopsin family) | 85.56446 | 0.000793 | ||
| Down | AJAP03092 | Unknown | PAT1 | Topoisomerase II-associated protein PAT1 | 0.001082 | 8.12E-20 | |
| AJAP25354 | Egg coat matrix protein | F5_F8_type_C | F5/8 type C domain | 0.00125 | 1.47E-33 | ||
| AJAP21569 | Uncharacterized protein LOC100377183 | CUB | CUB domain | 0.0015 | 7.12E-05 | ||
| AJAP20119 | Tnfrsf10b | Death | Death domain | 0.002005 | 4.04E-13 | ||
| AJAP03163 | G2/mitotic-specific cyclin-B-like | Cyclin_N | Cyclin, N-terminal domain | 0.005044 | 7.17E-10 | ||
| AJAP27549 | Uncharacterized protein LOC105442568 | HYR | HYR domain | 0.005891 | 4.36E-06 | ||
| AJAP10472 | Unknown | PTCB-BRCT | twin BRCT domain | 0.005997 | 1.83E-11 | ||
| AJAP18483 | Hypothetical protein NEMVEDRAFT_v1g77984 | DUF946 | Plant protein of unknown function (DUF946) | 0.006168 | 1.60E-34 | ||
| AJAP15987 | RNA-directed DNA polymerase from mobile element jockey | RVT_1 | Reverse transcriptase (RNA-dependent DNA polymerase) | 0.007862 | 1.43E-05 | ||
| AJAP13663 | Uncharacterized protein LOC106640225 | Pkinase_Tyr | Protein tyrosine kinase | 0.008102 | 3.13E-05 | ||
| HL | Up | AJAP20068 | Unknown | Corona_S2 | Coronavirus S2 glycoprotein | 1962.088 | 6.53E-07 |
| AJAP08436 | Uncharacterized protein LOC593642 isoform X1 | CAP | Cysteine-rich secretory protein family | 1076.098 | 3.11E-18 | ||
| AJAP27125 | Uncharacterized protein LOC593642 isoform X2 | CAP | Cysteine-rich secretory protein family | 702.1943 | 3.96E-14 | ||
| AJAP06450 | Heat shock protein 70 | HSP70 | Hsp70 protein | 227.2571 | 4.83E-08 | ||
| AJAP13651 | Heat shock protein 70 | HSP70 | Hsp70 protein | 217.2363 | 4.25E-24 | ||
| AJAP04789 | Heat shock protein 70 | HSP70 | Hsp70 protein | 214.3136 | 7.49E-11 | ||
| AJAP09309 | Heat shock protein 26 | HSP20 | Hsp20/alpha crystallin family | 180.2091 | 2.33E-26 | ||
| AJAP08960 | Uncharacterized protein LOC105440841 | zf-C3HC4_3 | Zinc finger, C3HC4 type (RING finger) | 173.2438 | 1.97E-05 | ||
| AJAP30268 | chymotrypsinogen B-like | Trypsin | Trypsin | 157.7697 | 0.000302 | ||
| AJAP22404 | Heat shock protein 70 | HSP70 | Hsp70 protein | 149.4496 | 2.88E-12 | ||
| Down | AJAP09945 | Egg coat matrix protein | 7TM_GPCR_Srd | Serpentine type 7TM GPCR chemoreceptor Srd | 0.000391 | 1.34E-30 | |
| AJAP03163 | G2/mitotic-specific cyclin-B-like | Cyclin_N | Cyclin, N-terminal domain | 0.000428 | 2.66E-16 | ||
| AJAP08602 | Unknown | Na_H_antiporter | Na+/H+ antiporter family | 0.000641 | 3.23E-22 | ||
| AJAP25354 | Egg coat matrix protein | F5_F8_type_C | F5/8 type C domain | 0.000865 | 1.92E-05 | ||
| AJAP03092 | Unknown | PAT1 | Topoisomerase II-associated protein PAT1 | 0.001134 | 2.17E-16 | ||
| AJAP02469 | Unknown | DUF1356 | Protein of unknown function (DUF1356) | 0.001733 | 4.73E-13 | ||
| AJAP26073 | Flocculation protein FLO11 | VWD | von Willebrand factor type D domain | 0.003828 | 1.58E-07 | ||
| AJAP18041 | Cell division cycle 2 | Pkinase | Protein kinase domain | 0.00605 | 2.27E-05 | ||
| AJAP10472 | Unknown | PTCB-BRCT | twin BRCT domain | 0.00612 | 1.22E-15 | ||
| AJAP19418 | Acetylcholinesterase-like | COesterase | Carboxylesterase family | 0.00656 | 1.65E-09 | ||