Table 4.
Pharmacokinetic parameters of KD025 after single oral (5 mg/kg, n = 5) and intravenous (2 mg/kg, n = 5) administrations to rats (mean ± standard deviations).
| Pharmacokinetic Parameters | PO | IV |
|---|---|---|
| Tmax (min) | 132.0 ± 78.2 | - |
| Cmax (ng/mL) | 128.4 ± 74.7 | 4415.7 ± 1208.7 a |
| T1/2 (min) | 353.4 ± 169.3 | 88.3 ± 19.9 |
| AUClast (μg∙min/mL) | 45.8 ± 12.7 | 52.3 ± 9.9 |
| AUC∞ (μg∙min/mL) | 48.7 ± 11.8 | 52.7 ± 10.0 |
| AUC∞ /Dose (μg∙min/mL/[mg/kg]) | 9.7 ± 2.4 | 26.3 ± 5.0 |
| MRT (min) | 474.8 ± 224.9 | 46.4 ± 8.1 |
| CL (mL/min/kg) | - | 38.9 ± 6.2 |
| Vss (mL/kg) | - | 1780.6 ± 286.9 |
| Bioavailability b (%) | 37.0% | - |
a Cmax for IV refers to C0, estimated by noncompartmental analysis; b Bioavailability = AUC∞PO/AUC∞IV × 100