Skip to main content
. 2020 Mar 19;25(6):1409. doi: 10.3390/molecules25061409

Table 1.

Cytotoxicity and antiviral activity of novel 2-benzoxyl-phenylpyridine derivatives against Coxsackievirus B3 (CVB3) and adenovirus type 7 (ADV7).

Compound Structure Compound Number CVB3 ADV7
EC50 a
(μM)		 CC50 b
(μM)		 SI c EC50
(μM)		 CC50
(μM)		 SI
graphic file with name molecules-25-01409-i001.jpg W1 - 594.2 ± 49.1d - - 1057.1 ± 93.5 -
graphic file with name molecules-25-01409-i002.jpg W2 100.7 ± 14.1 240.3 ± 22.0 2.4 50.8 ± 16.7 >655.7 >12.9
graphic file with name molecules-25-01409-i003.jpg W3 - 630.4 ± 39.4 - - 920.8 ± 59.5 -
graphic file with name molecules-25-01409-i004.jpg W4 54.4 ± 11.1 221.6 ± 24.1 4.1 - 796.9 ± 45.7 -
graphic file with name molecules-25-01409-i005.jpg W5 - 33.5 ± 9.4 - - 38.9 ± 18.8 -
graphic file with name molecules-25-01409-i006.jpg W6 88.4 ± 19.5 243.9 ± 30.4 2.8 66.0 ± 20.1 325.7 ± 21.8 4.9
graphic file with name molecules-25-01409-i007.jpg W7 - 349.5 ± 28.8 - - 1029.8 ± 63.1 -
graphic file with name molecules-25-01409-i008.jpg W8 80.1 ± 15.0 354.4 ± 49.5 4.4 - 842.7 ± 37.1 -
graphic file with name molecules-25-01409-i009.jpg W9 24.6 ± 8.7 148.0 ± 11.6 6.0 27.1 ± 9.0 265.3 ± 28.1 9.8
graphic file with name molecules-25-01409-i010.jpg W10 36.7 ± 15.8 184.2 ± 26.3 5.0 51.1 ± 20.1 249.2 ± 23.2 4.9
graphic file with name molecules-25-01409-i011.jpg W11 - 378.3 ± 19.2 - - 1023.8 ± 72.6 -
graphic file with name molecules-25-01409-i012.jpg W12 - 128.0 ± 17.9 - 63.6 ± 16.6 211.4 ± 14.7 3.3
graphic file with name molecules-25-01409-i013.jpg W13 41.6 ± 11.5 423.8 ± 26.8 10.2 36.4 ± 16.4 >371.7 >10
graphic file with name molecules-25-01409-i014.jpg W14 87.1 ± 21.1 490.5 ± 26.8 5.6 75.4 ± 20.2 979.2 ± 27.8 13.0
graphic file with name molecules-25-01409-i015.jpg W15 69.7 ± 15.0 451.4 ± 32.4 6.5 65.2 ± 21.6 794.9 ± 33.8 12.2
graphic file with name molecules-25-01409-i016.jpg Ribavirin e 101.2 836.5 8.3 114.3 806.6 7.1

a EC50: compound concentration required to achieve 50% protection from virus-induced cytopathogenicity; b CC50: compound concentration required to reduce cell viability by 50%; c SI (selectivity index): ratio by CC50/EC50; d Values represent the mean ± SD of three independent experiments; e Ribavirin, used as a positive control.