Scheme 18.
Synthesis of intermediate 74. Reagents and conditions: (i) EDCI, HOBT, HNMeOMe.HCl. TEA, 24 h, 70%; (ii) NaH, DMF, PMB-Cl, 18 h, 32%; (iii) vinylMgBr, THF, 0 °C then 14, H2O, 64%.
Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.