Table 1.

Summary of the metabolic parameters of Ip6k1-KO [22,30,41], AdKO [29], Ip6k3-KO [34] and TNP-treated WT [42] mouse models in ambient temperature conditions. Symbols ↑, ↓ and = denote increase, decrease and no change, respectively. # indicates that the study was done in 18-month old Ip6k1-KO mice instead of middle-aged (10-month) mice. Blank denotes that the parameter was not measured. Parameters that were measured in only one model are not included. For Ip6k1-KO [40] and AdKO [29] mice, some parameters were assessed in thermoneutral conditions, which are not included.

	Ip6k1-KO	Ip6k1-KO	Ip6k1-KO	AdKO	Ip6k3-KO	WT+TNP
	Adult-chow	Adult-HFD	Middle-Aged-Chow	Adult-HFD	Aged-Chow	Adult-HFD
Body and Fat Mass
Body mass	↓	↓	↓	↓	↓	↓
Fat mass (Total)	↓	↓	↓	↓	↓	↓
Lean mass (total)	=	↓	↓	↓	=	=
Fat mass (% total body weight)	↓	↓	↓	↓		↓
Lean mass (% total body weight)	↑	↑	↑	↑		↑
Energy Expenditure	=	↑		↑		↑
Food Intake	=	=		=		=
Serum Metabolic Parameters
Insulin	↓	↓	↓	↓	↓	↓
Glucose	=	↓	↓	↓	↓	↓
Insulin Sensitivity	↑	↑	↑	↑	↑	↑
Cholesterol (total)	=	↓	↓			↓
Triglycerides	↓	↓				=
AST	=	↓	=			↓
ALT			=			=
LDH	=	↓
Adiponectin		↑		↑
Leptin	↓	↓
Adipose Tissue/Adipocytes
Adipose tissue weight	↓	↓	↓	↓		↓
Adipocyte size	↓	↓	↓	↓		↓
Browning/UCP1 expression	↑	↑		↑		↑
Oxygen consumption rate	↑			↑
Liver
Liver weight	=	↓		↓		↓
Liver fat	↓	↓	↓	↓		↓
Bone Marrow Stem Cells
Survival and yield	↑		↑#			↑
Adipogenesis/marrow adiposity	↓		↓#			↓
Osteogenesis	↑		↑#