TABLE 1.
Characteristics of pediatric AML patients who underwent ISD‐SCT or HID‐SCT
| ISD‐SCT | HID‐SCT | ||
|---|---|---|---|
| Characteristic | (n = 23) | (n = 69) | P value |
| Age of recipients [years, median (range)] | 11 (4‐18) | 12 (1‐16) | 0.805 |
| Sex of recipients [cases (%)] | 1.000 | ||
| Male | 14 (60.9%) | 42 (60.9%) | |
| Female | 9 (39.1%) | 27 (39.1%) | |
| WBC at diagnosis (range, × 109/L) | 19.9 (2.1‐227.9) | 19.9 (0.3‐404.0) | 0.334 |
| Time from diagnosis to SCT (range, months) | 5.5 (1.0‐30.0) | 6.0 (1.0‐84.0) | 1.000 |
| Cytogenetic risk | 0.126 | ||
| Favorable | 3 (13.0%) | 3 (4.3%) | |
| Intermediate | 8 (34.8%) | 40 (58.0%) | |
| Adverse | 8 (34.8%) | 13 (18.8%) | |
| Unknown | 4 (17.4%) | 13 (18.8%) | |
| Diseases status | 0.569 | ||
| CR1 | 17 (73.9%) | 55 (79.7%) | |
| Beyond CR1 | 6 (26.1%) | 14 (20.3%) | |
| ABO incompatibility | 0.007 | ||
| Match | 21 (91.3%) | 36 (52.2%) | |
| Minor mismatch | 0 | 21 (30.4%) | |
| Major mismatch | 1 (4.3%) | 8 (11.6%) | |
| Bidirectional mismatch | 1 (4.3%) | 4 (5.8%) | |
| Age of donors (range, years) | 16 (6‐31) | 37 (11‐52) | <0.001 |
| Sex of donors | 0.159 | ||
| Male | 9 (39.1%) | 39 (56.5%) | |
| Female | 14 (60.9%) | 30 (43.5%) | |
| Graft source | 0.307 | ||
| BM+PBSC | 14 (60.9%) | 50 (72.5%) | |
| PB | 9 (39.1%) | 19 (27.5%) | |
| Median MNC (range, × 108/kg) | 8.48 (5.43‐15.82) | 9.15 (3.19‐29.60) | 0.630 |
| Median CD34(range, × 106/kg) | 3.29 (1.10‐6.20) | 3.29 (0.52‐10.00) | 1.000 |
| Transplant center | 0.505 | ||
| Peking University People's Hospital | 14 (60.9%) | 39 (56.5%) | |
| Xinqiao Hospital, Army Military Medical University | 7 (30.4%) | 17 (24.6%) | |
| Nanfang Hospital, Southern Medical University | 2 (8.7%) | 13 (18.8%) |
AML, acute myeloid leukemia; SCT, stem cell transplantation; ISD, identical sibling donor; HID, haploidentical donor; WBC, white blood cell; CR1, first complete remission; BM, bone marrow; PBSC, peripheral blood stem cell; MNC, mononuclear cell.