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. 2020 Jan 9;217(4):e20190930. doi: 10.1084/jem.20190930

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© 2020 Liu et al.

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Figure 5. — Epac inhibitor prevents RGC loss after IR injury. (A) Active Rap1 in control and injured-retinas from vehicle (Veh) or ESI-09–treated WT mice 3 h after IR. n = 3. (B) Representative images of retinal flatmounts labeled with Tuj1 antibody (green) 7 d after IR in vehicle- or ESI-09-treated WT mice. Bar graph represents the percentage of Tuj1-positive cells per field relative to vehicle-treated control retinas. Scale bar: 50 µm. n = 6–10 mice; eight images were taken at the peripheral retina for each sample and calculated as average value. ***, P < 0.001; ****, P < 0.0001; one-way ANOVA. Error bars represent SEM.