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. 2020 Jan 16;217(4):e20190762. doi: 10.1084/jem.20190762

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© 2020 Kang et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).

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Figure 8. — A schematic model for the dynamical regulation of colonic macrophage–mediated immune responses against enteric bacterial infections by RBP-J. RBP-J is a crucial regulator in colonic macrophage–mediated immune responses against the enteric pathogen C. rodentium. In the immune response phase (phase A), RBP-J KO mice exhibit compromised clearance of pathogens due to diminished IL-6–induced Th17 immune responses secondary to up-regulation of the miRNA-17∼92 cluster and subsequent suppression of C/EBPβ protein expression. In the late phase (phase B), RBP-J KO mice eventually clear C. rodentium owing to late persistence of pathogen-dependent ILC3-derived IL-22 activated by CD64⁺Ly6C⁺ colonic macrophages.