Figure S2.

Unaltered Kupffer cell size and recruitment of desialylated platelets but reduced fenestrations in mice after arsenic treatment. Mice were treated with arsenic in their drinking water for 5 wk. (A) Quantification of the Kupffer cell size from SD-IVM images. Data represent means ± SEM (n = 5 mice). (B) Quantification of the accumulation of platelets in the liver after sialidase treatment. n = 5 mice. (C and D) Representative scanning EM images of the liver sinusoids show less fenestrations (arrows) after arsenic treatment. Scale bars are 2 µm. Unpaired two-tailed t test (A) was used to determine statistical significance. ns, not significant. Results from all experiments shown are representative of at least three independent experiments.