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. 2020 Jan 30;217(4):e20182091. doi: 10.1084/jem.20182091

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© 2020 Tang et al.

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Figure S2. — Innate immune cells are essential for the hypersensitivity to a sub-lethal dose of LPS-induced endotoxemia in the absence of Cbl-b. Related to Fig. 2. (A) Survival rate of Rag1^−/− and Rag1^−/−Cblb^−/− mice (n = 8 per group) after injection of LPS (2 mg/kg). **, P < 0.01; log-rank test. (B) Immunoblot analysis of lysates of T cells (T), B cells (B), and BMDMs (Mac) from LysM Cre (WT) and LysM Cre-Cblb^f/f (KO) mice with antibodies against CBLB and actin. (C) Survival rate of LysM Cre and LysM Cre-Cblb^f/f mice (n = 6 per group) after injection of LPS (5 mg/kg). **, P < 0.01; log-rank test. Data are representative of two independent experiments.