Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Mar 25;217(4):e20190062. doi: 10.1084/jem.20190062

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020 Profaci et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).

PMC Copyright notice

Figure 1. — Cellular and molecular properties of the BBB. (A) A schematic comparison of the BBB capillaries with the continuous nonfenestrated, continuous fenestrated, and discontinuous capillaries found in peripheral organs. (B–F) Schematics of the molecular composition of junctional complexes of BBB ECs (B) and of ECs in peripheral organs (C), peripheral endothelial fenestra (D), and transport mechanisms in CNS ECs (E) and peripheral ECs (F). (G and H) Electron micrographs of a mouse brain EC (G) and a mouse muscle EC, which is densely packed with vesicles (arrows; H). BCRP, breast cancer resistance protein; GLUT1, glucose transporter 1; ICAM, intercellular adhesion molecule; JAM, junctional adhesion molecule; LAT1, L-type amino acid transporter 1; MRP, multidrug resistance-associated protein; PECAM-1, platelet and EC adhesion molecule 1; P-GP, p-glycoprotein; VE-cadherin, vascular endothelial cadherin; P-sel, P-selectin; E-sel, E-selectin.