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. 2020 Apr 9;181(4):894–904.e9. doi: 10.1016/j.cell.2020.03.045

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© 2020 Elsevier Inc.

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Different Antigenicity between the SARS-CoV-2 S and SARS-CoV S Proteins

(A and B) HEK293T cells were transfected with pCAGGS plasmids containing Flag-tagged SARS-CoV S (A) or SARS-CoV-2 S (B). The indicated purified murine mAbs were subsequently added to the transfected cells before they were fixed, permeabilized, and stained with anti-Flag/fluorescein isothiocyanate (FITC).

(C and D) HEK293T cells were transfected with pCAGGS plasmids expressing Flag-tagged SARS-CoV S. The murine polyclonal sera against SARS-RBD (C) or MERS-RBD (D) were subsequently added to the transfected cells before they were fixed, permeabilized, and stained with anti-Flag/FITC.

(E and F) HEK293T cells were transfected with pCAGGS plasmids expressing Flag-tagged SARS-CoV-2 S. The murine polyclonal sera against SARS-RBD (E) or MERS-RBD (F) were subsequently added to the transfected cells before they were fixed, permeabilized, and stained with anti-Flag/FITC.

(G) Electrostatic surface view of SARS-CoV-2-CTD. The first panel represents the top view. The others are yielded by rotation of the former panel along a horizontal axis.

(H) Electrostatic surface view of SARS-RBD. The first panel represents the top view. The others are yielded by rotation of the former panel along a horizontal axis.