Fig 3.

Dynamic MR thermometry following superselective right MCA endovascular stroke induction in an adult rhesus macaque using a low-profile suture embolus. DWI (A) obtained at approximately 7 hours following complete occlusion and contemporaneous 2D axial sLASER chemical shift thermography (see MR Thermometry in Stroke and Cerebrovascular Disease: Acute Ischemic Stroke) following automated and manual shimming (B) demonstrate extensive right-hemispheric ischemic injury and generalized cerebral hyperthermia, respectively. Through the course of the experiment, temperatures in both hemispheres were noted to rise, importantly with a differing temporal course and, in both cases, outpacing the influences of the steadily increasing systemic pyrexia (C), measured continuously from an indwelling rectal probe and aggregated over all subjects. The correlation between both normalized infarction size (C) and time from infarction relative to cerebral temperatures was similarly observed across all experimental NHP strokes, and aggregated results are depicted. Adapted from Dehkharghani et al.⁴¹