1 GM‐CSF versus G‐CSF |
13 |
2368 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.03 [0.95, 1.10] |
1.1 GM‐CSF |
2 |
228 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.07 [0.88, 1.31] |
1.2 G‐CSF |
11 |
2140 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.02 [0.94, 1.10] |
2 HD versus NHL |
13 |
2368 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.03 [0.95, 1.10] |
2.1 Hodgkin's disease |
3 |
106 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.23 [0.89, 1.72] |
2.2 Non‐Hodgkin's lymphoma |
10 |
2262 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.02 [0.94, 1.09] |
3 Age |
13 |
2368 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.03 [0.95, 1.10] |
3.1 Adults, all ages |
8 |
591 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.11 [0.98, 1.25] |
3.2 Adults, age older 60 |
5 |
1777 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.99 [0.91, 1.09] |
4 Use of antibiotic prophylaxis |
13 |
2368 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.03 [0.95, 1.10] |
4.1 No antibiotic prophylaxis given |
11 |
1435 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.02 [0.93, 1.11] |
4.2 Antibiotic prophylaxis given |
2 |
933 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.03 [0.91, 1.17] |
5 Blinded versus open label studies |
13 |
2368 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.03 [0.95, 1.10] |
5.1 Placebo controlled studies |
4 |
431 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.05 [0.92, 1.20] |
5.2 Open label studies |
9 |
1937 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.02 [0.94, 1.11] |
6 Published and reported data versus unpublished or unreported data |
13 |
2368 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.03 [0.95, 1.10] |
6.1 Data not published in a peer‐review journal |
3 |
89 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.58 [0.88, 2.86] |
6.2 Peer‐reviewed data |
10 |
2279 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.02 [0.94, 1.09] |
7 Size of studies |
13 |
2368 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.03 [0.95, 1.10] |
7.1 Study size n<100 |
6 |
258 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.31 [1.08, 1.60] |
7.2 Study size n>100 |
7 |
2110 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.99 [0.92, 1.07] |
8 Worst case ‐ best case |
15 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
Subtotals only |
8.1 Best case |
13 |
2405 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.05 [0.98, 1.13] |
8.2 Worst case |
13 |
2405 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.00 [0.93, 1.07] |