| Author |
Dose Intensity |
Substance |
G‐/GM‐CSF |
Control |
P value |
comments |
| Avilés 1994 |
defined as by Hryniuk |
Cyclophosphamide |
73%, N =20 |
61%, N =22 |
‐ |
P values were not specified. Overall more chemotherapeutic substances were used, but RDI not calculated by the study author. Not stated whether mean or median values. |
| |
|
Epirubicin |
82% |
51% |
‐ |
|
| |
|
Etoposide |
83% |
67% |
‐ |
|
| |
|
Cytosine arabinoside |
79% |
53% |
‐ |
|
| |
|
Mitoxantrone |
87% |
49% |
‐ |
|
| |
|
Procarbazine |
89% |
60% |
‐ |
|
| Ösby 2003 |
mean cumulative received dose intensity in cycle 8 |
Doxorubicin, Mitoxantrone, Cyclophosphamide |
CHOP: 92.6, SD = 9.4, CNOP: 92.3, SD = 8.68 |
CHOP: 88.8, SD = 10.09, CNOP: 89.8, SD = 10.17 |
not significant |
|
| Dunlop MOPP 1998 |
median received dose intensity |
MOPP |
84%, range 59‐103%, N =1 3 |
82%, range 57‐99%, N = 12 |
P = 0.57 |
|
| Dunlop MOPP/EVAP 98 |
median received dose intensity |
MOPP/EVAP |
96%, range 67‐105%, N = 12 |
97%, range 71‐104%, N = 10 |
P = 0.53 |
|
| Fridrik 1997 |
defined as by Hryniuk |
CEOP‐IMVP‐Dexa |
82.3%, N = 38 |
76.2%, N = 36 |
P = 0.041 |
not stated whether mean or median |
| Gerhartz 1993 |
defined as by Hryniuk; median received dose intensity |
COP‐BLAM |
median =85%, mean = 85% |
median = 84%, mean = 81% |
‐ |
efficiency analysis: based only on patients, that received more than 70% of the study drug, 137 of 172 pts evaluated |
| Gisselbrecht 1997 |
defined as by Hryniuk, mean received dose intensity |
adriamycin and cyclophosphamide |
93.3%, SD = 13.5, N = 73 |
80.1%, SD = 13, N = 63 |
P = 0.0001 |
evaluable for this analysis, more different substances were administered, but not calculated for RDI, only 136 of 162 pts evaluated |
| Pettengell 1992 |
defined as by Hryniuk, median received dose intensity |
Adriamycin |
96%, N = 39 |
85%, N = 41 |
P = 0.0004 |
|
| |
|
Cyclophosphamide |
96% |
83% |
P = 0.0001 |
|
| |
|
Etoposide |
94% |
82% |
P = 0.02 |
|
| Zinzani 1997 |
defined as by Hryniuk |
VNCOP‐B |
95%, N = 77 |
85%, N = 72 |
not significant |
not stated whether mean or median |
| Doorduijn 2003 |
median received dose intensity |
Cyclophosphamide |
96.3% |
93.9% |
P = 0.01 |
|
| |
|
Doxorubicin |
95.4% |
93.3% |
P = 0.04 |
|
| |
|
overall CHOP |
95.1% |
93.4% |
not significant |
|
