| Interventions |
1. CT
A: 3‐4 courses ACVBP, 21 days
B: 2 ACVBP alternat. 2x VIMMM, 21 days
ACVBP:
Adriamycin 75 mg/m², d1
Cyclophsophamide 1200 mg/m², d1
Vindesine 2 mg/m², d1 and 5
Bleomycin 10 mg, d1 and 5
Prednisolone 60 mg/m², d1‐5
Methotrexate 12 mg intrathecal 1‐2 /week
VIMMM:
VP 16 100 mg/m², d1 and 5
Ifosfamide 1000 mg/m², d1‐5
Mitoxantrone 10 mg/m², d1
Methyl GAG 300 mg/m², d1 and 5
Methotrexate 1500 mg/m², d15
Methylprednison 60 mg/m², d1‐5
2. G‐CSF: 5 µg/kg/day, sc, d6‐max d19)
3. placebo given
4. no AB prophylaxis |
