Skip to main content
. Author manuscript; available in PMC: 2021 Mar 19.
Published in final edited form as: Cell Chem Biol. 2020 Feb 3;27(3):292–305.e6. doi: 10.1016/j.chembiol.2020.01.008

Figure 6. SAR analyses identifies key structural elements in SEW84.

Figure 6.

A-B. Bar graph depicting the normalized fluorescence of the ASH activity assay in the presence of DMSO, 50 μM GA or 20 μM of the indicated SEW84 analog (A90). C. Table depicting the IC50 values of the indicated compound. D. Chemical structure of SEW84 depicting the permissive (green) and inhibitory (red) changes allotted. In all panels the error bars represent standard deviations (n ≥ 3). The asterisk indicates p < 0.05 using a two-tailed t-test with the vehicle control used as a reference and the hashtag represents p < 0.05 using a two-tailed t-test with the SEW84 used as a reference.