Comparison 4. combined regimen mifepristone/prostaglandin: time of prostaglandin.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 failure to achieve complete abortion	7		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
1.1 day 3 vs day 1	1	1489	Risk Ratio (M‐H, Fixed, 95% CI)	1.94 [1.05, 3.58]
1.2 day 3 vs day 2	1	1521	Risk Ratio (M‐H, Fixed, 95% CI)	1.69 [0.95, 3.01]
1.3 day 2 vs day 1(all)	3	3687	Risk Ratio (M‐H, Fixed, 95% CI)	1.24 [0.95, 1.63]
1.4 day 2 vs day 1(</= 49 days)	1	941	Risk Ratio (M‐H, Fixed, 95% CI)	0.81 [0.49, 1.36]
1.5 day 2 vs day 1(> 49 days)	1	1182	Risk Ratio (M‐H, Fixed, 95% CI)	1.62 [1.11, 2.38]
1.6 day 2 vs day 0	2	511	Risk Ratio (M‐H, Fixed, 95% CI)	0.39 [0.24, 0.65]
1.7 day 1 vs day 0(all)	2	2156	Risk Ratio (M‐H, Fixed, 95% CI)	0.65 [0.46, 0.92]
1.8 day 1 vs day 0(</= 49 days)	2	998	Risk Ratio (M‐H, Fixed, 95% CI)	0.65 [0.38, 1.14]
1.9 day 1 vs day 0(> 49 days)	2	1158	Risk Ratio (M‐H, Fixed, 95% CI)	0.66 [0.41, 1.06]
2 side effects	5		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
2.1 nausea day 3 vs day 1	1	1358	Risk Ratio (M‐H, Fixed, 95% CI)	1.05 [0.96, 1.14]
2.2 nausea day 3 vs day 2	1	1384	Risk Ratio (M‐H, Fixed, 95% CI)	0.98 [0.91, 1.06]
2.3 nausea day 2 vs day 1	1	1434	Risk Ratio (M‐H, Fixed, 95% CI)	1.07 [0.98, 1.16]
2.4 nausea day 2 vs day 0	2	444	Risk Ratio (M‐H, Fixed, 95% CI)	0.80 [0.58, 1.11]
2.5 vomiting day 3 vs day 1	1	1358	Risk Ratio (M‐H, Fixed, 95% CI)	1.01 [0.86, 1.19]
2.6 vomiting day 3 vs day 2	1	1384	Risk Ratio (M‐H, Fixed, 95% CI)	0.97 [0.83, 1.13]
2.7 vomiting day 2 vs day 1	1	1434	Risk Ratio (M‐H, Fixed, 95% CI)	1.05 [0.90, 1.22]
2.8 vomiting day 2 vs day 0	2	444	Risk Ratio (M‐H, Fixed, 95% CI)	0.90 [0.59, 1.36]
2.9 diarrhoea day 3 vs day 1	1	1358	Risk Ratio (M‐H, Fixed, 95% CI)	1.21 [0.99, 1.48]
2.10 diarrhoea day 3 vs day 2	1	1384	Risk Ratio (M‐H, Fixed, 95% CI)	1.16 [0.95, 1.42]
2.11 diarrhoea day 2 vs day 1	1	1434	Risk Ratio (M‐H, Fixed, 95% CI)	1.04 [0.85, 1.28]
2.12 diarrhoea day 2 vs day 0	2	444	Risk Ratio (M‐H, Fixed, 95% CI)	0.65 [0.41, 1.03]
2.13 nausea day 1 vs day 0	2	2137	Risk Ratio (M‐H, Fixed, 95% CI)	1.01 [0.78, 1.31]
2.14 vomiting day 1 vs day 0	2	2137	Risk Ratio (M‐H, Fixed, 95% CI)	1.13 [0.79, 1.62]
2.15 diarrhoea day 1 vs day 0	2	2137	Risk Ratio (M‐H, Fixed, 95% CI)	0.83 [0.58, 1.18]
3 surgical evacuation	5	8330	Risk Ratio (M‐H, Fixed, 95% CI)	0.98 [0.76, 1.27]
3.1 day 3 vs day 1	1	1489	Risk Ratio (M‐H, Fixed, 95% CI)	1.49 [0.78, 2.83]
3.2 day 3 vs day 2	1	1521	Risk Ratio (M‐H, Fixed, 95% CI)	1.80 [0.92, 3.52]
3.3 day 2 vs day 1	2	3681	Risk Ratio (M‐H, Fixed, 95% CI)	1.06 [0.68, 1.67]
3.4 day 2 vs day 0	2	511	Risk Ratio (M‐H, Fixed, 95% CI)	0.40 [0.19, 0.85]
3.5 day 1 vs day 0	1	1128	Risk Ratio (M‐H, Fixed, 95% CI)	0.66 [0.36, 1.20]
4 ongoing pregnancy	4		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
4.1 day 3 vs day 1	1	1489	Risk Ratio (M‐H, Fixed, 95% CI)	1.56 [0.51, 4.73]
4.2 day 3 vs day 2	1	1521	Risk Ratio (M‐H, Fixed, 95% CI)	2.71 [0.72, 10.16]
4.3 day 2 vs day 1 (all)	2	3681	Risk Ratio (M‐H, Fixed, 95% CI)	0.92 [0.45, 1.90]
4.4 day 1 vs day 0	2	2208	Risk Ratio (M‐H, Fixed, 95% CI)	0.34 [0.07, 1.66]
5 women dissatisfied with the procedure	1	1349	Risk Ratio (M‐H, Fixed, 95% CI)	1.00 [0.68, 1.47]