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. 2011 Nov 9;2011(11):CD002855. doi: 10.1002/14651858.CD002855.pub4

Comparison 7. combined regimen mifepristone/prostaglandin: misoprostol buccal vs oral.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 failure to achieve complete abortion 1   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
1.1 failure to achieve complete abortion (all) 1 847 Risk Ratio (M‐H, Fixed, 95% CI) 0.62 [0.40, 0.96]
1.2 failure to achieve complete abortion </= 49 days 1 418 Risk Ratio (M‐H, Fixed, 95% CI) 0.72 [0.25, 2.04]
1.3 failure to achieve complete abortion > 49 days 1 429 Risk Ratio (M‐H, Fixed, 95% CI) 0.37 [0.18, 0.73]
2 ongoing pregnancy 1 847 Risk Ratio (M‐H, Fixed, 95% CI) 0.27 [0.09, 0.82]
2.1 ongoing pregnancy </= 49 days 1 418 Risk Ratio (M‐H, Fixed, 95% CI) 0.64 [0.11, 3.80]
2.2 ongoing pregnancy >49 days 1 429 Risk Ratio (M‐H, Fixed, 95% CI) 0.18 [0.04, 0.78]
3 side effects 1   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
3.1 nausea 1 830 Risk Ratio (M‐H, Fixed, 95% CI) 1.10 [1.01, 1.19]
3.2 vomiting 1 830 Risk Ratio (M‐H, Fixed, 95% CI) 1.09 [0.94, 1.27]
3.3 diarrhoea 1 830 Risk Ratio (M‐H, Fixed, 95% CI) 1.11 [0.94, 1.31]
4 women dissatisfied with the procedure 1 835 Risk Ratio (M‐H, Fixed, 95% CI) 1.21 [0.76, 1.91]